Protein Details: Glutamate receptor ionotropic; NMDA 1

Protein ID

ICDB_Pro_0006

Protein Name

Glutamate receptor ionotropic; NMDA 1

Gene Name

grin1

Organism

Xenopus laevis (African clawed frog)

Length

903 amino acids

AlphaFoldDB

AF-A0A1L8F5J9-F1-model_v4.pdb

Function

Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).

Sequence

MGTMRLFLLAVLFLFSFARAGCDPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFANYSIMNLQNRKLVQVGIFNGSYIIQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCVDLLIKLAREMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFMEELDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTVNVVV

PDB Structures

3QEK 3QEL 3QEM 4TLL 4TLM 5B3J 5EWJ 5EWL 5EWM 5IOU 5IOV 5IPQ 5IPR 5IPS 5IPT 5IPU 5IPV 5TPW 5TPZ 5TQ0 5TQ2 5UN1 5UOW 5UP2 6E7R 6E7S 6E7T 6E7U 6E7V 6E7W 6E7X 7TE6

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 67; /ligand="Zn(2+)"; BINDING 94; /ligand="Zn(2+)"; BINDING 100; /ligand="Zn(2+)"; BINDING 514..516; /ligand="glycine"; BINDING 521; /ligand="glycine"; BINDING 686; /ligand="glycine"; BINDING 730; /ligand="glycine";

Disease

Location

DOI ID

10.1074/jbc.271.51.32572; 10.1124/mol.105.016840; 10.1016/j.mcn.2009.06.004; 10.1038/nature19840; 10.1038/nature10180; 10.1038/nature13548; 10.1016/j.cell.2016.03.028; 10.1124/mol.115.103036; 10.1038/nature17679; 10.1016/j.neuron.2016.11.006; 10.1126/science.aal3729

RefSeq

NP_001081615.1 [A0A1L8F5J9-8]; NP_001081616.1 [A0A1L8F5J9-7]